Humanitarian work
Kyagulanyi has supported several practical projects to improve conditions for the poor. In 2012, he started a campaign to promote more regular cleaning in hospitals, sanitation, garbage management, and hand-washing to prevent disease.
In 2012 he donated funds to build pit latrines and construct a drainage channel in Kisenyi II, a Kampala slum that the New Vision described as being "characterized by filth, crowded shanty structures, poor sanitation and lack of basic social facilities." Kyagulanyi explained that he embarked on the project "because these are my people, and no matter where I go, this will always be home.”
He has also campaigned for malaria prevention, with donations to Nakasongola Health Centre, and references to the disease in his songs.
In August 2013, Kyagulanyi visited the Bundibugyo Refugee Camp in Bundibugyo District, along with representatives from Save the Children, UNHCR, and the Red Cross, to deliver funds and supplies.
The following month, he was named as a parenting ambassador by Twaweza, an NGO that focuses on education and citizen engagement in East Africa; his message in this partnership was to promote responsible parenting among his Ugandan fans. In an interview about the project, he said that "education is what will ultimately change the course of our country and as an artiste and a father, I believe we can all make a difference in our children's learning.
In 2014, Kyagulanyi was named as an ambassador for Save the Children's EVERY ONE campaign, joining a team of 14 Ugandan artists who recorded a special song and video about maternal and child health. Other leading artists in the video included Jose Chameleone, and Radio and Weasel, who made up the Goodlyfe Crew.
Kyagulanyi and his wife Barbara travelled to hospitals throughout Uganda, including Nakaseke Hospital, meeting with midwives and health workers to popularize the campaign. Save the Children also took him to other regions for the campaign, including Nyumanzi Refugee Settlement in northwestern Uganda for South Sudanese people.
Currently, Bobi Wine is the Patron of a girls and teen mothers’ empowerment Non-Government Organization called Caring Hearts Uganda, founded by his wife Barbie Kyagulanyi. About Caring Hearts Uganda - Nonprofit for menstrual health in Uganda.
Kyagulanyi was scheduled to perform a show in Dubai, United Arab Emirates on October 8, 2022, and the proceeds from the show were going to be used to repatriate Ugandans stranded in the United Arab Emirates. However, the show was canceled by the United Arab Emirates government on unknown grounds and upon arrival in Dubai, Kyagulanyi was detained at the airport for ten hours. He was later released and spoke to support.